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| Date | Location | Result | |
| 02/19/22 | Winona, MN | St. Olaf 62, Saint Mary's (MN) 57 | Box score |
| 02/16/22 | Saint Paul, MN | St. Catherine 63, Saint Mary's (MN) 42 | Box score |
| 02/14/22 | Northfield, MN | Carleton 54, Saint Mary's (MN) 52 | Box score |
| 02/12/22 | Winona, MN | Saint Mary's (MN) 71, Concordia-M'head 54 | Box score |
| 02/09/22 | Si Melby Hall, Minneapolis, Minn. | Augsburg University 64, Saint Mary's Univ. 56 | Box score |
| 02/07/22 | Northfield, MN | Saint Mary's (MN) 66, St. Olaf 57 | Box score |
| 02/05/22 | St. Paul, MN | Bethel (MN) 73, Saint Mary's (MN) 29 | Box score |
| 02/02/22 | Winona, MN | Saint Mary's (MN) 67, Gust. Adolphus 64 | Box score |
| 01/29/22 | Winona, MN | Saint Mary's (MN) 72, St. Scholastica 68 | Box score |
| 01/26/22 | Saint Paul, MN | Hamline 67, Saint Mary's (MN) 52 | Box score |
| 01/22/22 | Winona, MN | Macalester 64, Saint Mary's (MN) 57 | Box score |
| 01/19/22 | Winona, MN | Saint Benedict 69, Saint Mary's (MN) 53 | Box score |
| 01/15/22 | Moorhead, Minn. (Memorial Auditorium) | Concordia-M'head 62, Saint Mary's (Minn.) 41 | Box score |
| 01/12/22 | Winona, MN | St. Catherine 71, Saint Mary's (MN) 61 | Box score |
| 01/10/22 | Winona, MN | Augsburg 56, Saint Mary's (MN) 49 | Box score |
| 01/08/22 | Winona, MN | Saint Mary's (MN) 85, Carleton 58 | Box score |
| 01/05/22 | Saint Peter, MN | Gust. Adolphus 81, Saint Mary's (MN) 49 | Box score |
| 12/11/21 | Winona, MN | Bethel (MN) 65, Saint Mary's (MN) 51 | Box score |
| 12/08/21 | Winona, MN | St. Olaf 72, Saint Mary's (MN) 63 | Box score |
| 12/04/21 | Duluth, MN | Saint Mary's (MN) 65, St. Scholastica 57 | Box score |
| 12/01/21 | St. Joseph, MN | Saint Benedict 59, Saint Mary's (MN) 56 | Box score |
| 11/28/21 | Winona, MN | Luther 81, Saint Mary's (MN) 56 | Box score |
| 11/23/21 | Winona, MN | Hamline 75, Saint Mary's (MN) 71 (OT) | Box score |
| 11/20/21 | Saint Paul, MN | Saint Mary's (MN) 63, Macalester 58 | Box score |
| 11/15/21 | New Ulm, MN | Saint Mary's (MN) 80, Martin Luther 74 | Box score |
| 11/09/21 | Stevens Point, WI | Wis.-Stevens Point 73, Saint Mary's (MN) 58 | Box score |