| Date | Location | Result | |
| 10/30/21 | Winona, MN | Gust. Adolphus 3, Saint Mary's 0 (25-15,25-16,25-21) | Box score |
| 10/27/21 | Winona, MN | St. Olaf 3, Saint Mary's 0 (27-25,25-15,28-26) | Box score |
| 10/23/21 | Winona, MN | Bethel (MN) 3, Saint Mary's 0 (25-20,25-17,25-21) | Box score |
| 10/22/21 | Winona, MN | Macalester 3, Saint Mary's 2 (29-27,10-25,28-26,22-25,15-12) | Box score |
| 10/16/21 | Moorhead, Minn. | Concordia-M'head 3, Saint Mary's 1 (23-25,25-22,25-16,25-17) | Box score |
| 10/15/21 | St. Joseph, MN | Saint Benedict 3, Saint Mary's 0 (25-17,25-17,25-17) | Box score |
| 10/12/21 | La Crosse, WI | Wis.-La Crosse 3, Saint Mary's 0 (25-15,25-16,25-15) | Box score |
| 10/08/21 | Winona, MN | Hamline 3, Saint Mary's 0 (25-14,25-17,25-15) | Box score |
| 10/02/21 | Saint Paul, MN | Saint Mary's 3, St. Catherine 0 (25-23,25-19,25-21) | Box score |
| 10/01/21 | Winona, MN | Saint Mary's 3, St. Scholastica 1 (25-19,22-25,25-16,25-18) | Box score |
| 09/25/21 | Whitewater, WI | Carthage 3, Saint Mary's 0 (25-21,25-21,25-19) | Box score |
| 09/25/21 | Whitewater, WI | Wis.-Whitewater 3, Saint Mary's 0 (25-21,25-12,25-12) | Box score |
| 09/24/21 | Whitewater, Wis. | Carroll 3, Saint Mary's 2 (25-23,25-17,21-25,21-25,15-12) | Box score |
| 09/24/21 | Whitewater, WI | Concordia Wisconsin 3, Saint Mary's 0 (25-20,25-12,25-17) | Box score |
| 09/22/21 | Minneapolis, MN | Augsburg 3, Saint Mary's 0 (25-20,25-18,25-14) | Box score |
| 09/18/21 | Dubuque, Iowa | Loras 3, Saint Mary's 1 (25-18,25-22,25-27,25-16) | Box score |
| 09/17/21 | Dubuque, Iowa | Saint Mary's 3, Westminster (MO) 1 (18-25,32-30,25-14,25-14) | Box score |
| 09/17/21 | Dubuque, Iowa | Dubuque 3, Saint Mary's 0 (25-20,25-16,25-14) | Box score |
| 09/15/21 | Northfield, MN | Saint Mary's 3, Carleton 2 (20-25,25-22,25-27,25-21,15-6) | Box score |
| 09/11/21 | Stevens Point, WI | Wis.-Stevens Point 3, Saint Mary's 0 (25-17,25-12,25-14) | Box score |
| 09/11/21 | Stevens Point, Wis. | Marian (WI) 3, Saint Mary's 2 (22-25,25-22,20-25,25-17,15-11) | Box score |
| 09/10/21 | Stevens Point, WI | Saint Mary's 3, Beloit 0 (25-13,25-19,25-23) | Box score |
| 09/08/21 | Menomonie, WI | Saint Mary's 3, Wis.-Stout 1 (26-24,13-25,25-17,25-21) | Box score |
| 09/04/21 | Waverly, IA | Wartburg 3, Saint Mary's 0 (25-16,25-22,25-16) | Box score |
| 09/04/21 | Waverly, Iowa | MSOE 3, Saint Mary's 1 (25-21,18-25,27-25,25-21) | Box score |
| Sep 03, 2021 | Decorah, IA | Edgewood 3, Saint Mary's 1 (22-25,25-22,25-14,25-19) | Box score |
| Sep 03, 2021 | Decorah, IA | Saint Mary's 3, Luther 0 (25-19,25-17,25-21) | Box score |