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| Date | Location | Result | |
| 02/19/22 | Saint Paul, MN | Hamline 89, Saint Mary's (MN) 64 | Box score |
| 02/14/22 | Northfield, MN | Carleton 76, Saint Mary's (MN) 66 (OT) | Box score |
| 02/12/22 | Winona, MN | Concordia-M'head 65, Saint Mary's (MN) 64 | Box score |
| 02/09/22 | Winona, MN | Augsburg 79, Saint Mary's (MN) 61 | Box score |
| 02/07/22 | Winona, MN | St. Olaf 65, Saint Mary's (MN) 64 | Box score |
| 02/05/22 | St. Paul, MN | Saint Mary's (MN) 77, Bethel (MN) 64 | Box score |
| 02/02/22 | Saint Peter, MN | Gust. Adolphus 73, Saint Mary's (MN) 70 | Box score |
| 01/29/22 | Winona, MN | Saint Mary's (MN) 77, St. Scholastica 59 | Box score |
| 01/26/22 | Winona, MN | Saint Mary's (MN) 69, Hamline 58 | Box score |
| 01/22/22 | Winona, MN | Macalester 76, Saint Mary's (MN) 72 | Box score |
| 01/19/22 | Collegeville, MN | Saint John's (MN) 80, Saint Mary's (MN) 53 | Box score |
| 01/15/22 | Moorhead, Minn. (Memorial Auditorium) | Concordia-M'head 73, Saint Mary's (Minn.) 67 | Box score |
| 01/08/22 | Winona, MN | Carleton 58, Saint Mary's (MN) 47 | Box score |
| 01/05/22 | Winona, MN | Gust. Adolphus 83, Saint Mary's (MN) 70 | Box score |
| 01/03/22 | Winona, MN | Saint Mary's (MN) 69, Crown (MN) 58 | Box score |
| 12/30/21 | Las Vegas, Nev. | Mary Hardin-Baylor 84, Saint Mary's (MN) 64 | Box score |
| 12/28/21 | Las Vegas, Nev. | Saint Mary's (MN) 83, Wis.-Superior 78 | Box score |
| 12/11/21 | Winona, MN | Bethel (MN) 70, Saint Mary's (MN) 58 | Box score |
| 12/08/21 | Northfield, Minn. - Skoglund Center | Saint Mary's (MN) 63, St. Olaf 60 | Box score |
| 12/04/21 | Duluth, MN | Saint Mary's (MN) 68, St. Scholastica 66 | Box score |
| 12/01/21 | Winona, MN | Saint John's (MN) 73, Saint Mary's (MN) 63 | Box score |
| 11/23/21 | Saint Paul, MN | Hamline 67, Saint Mary's (MN) 64 | Box score |
| 11/20/21 | Saint Paul, MN | Saint Mary's (MN) 63, Macalester 61 | Box score |
| 11/16/21 | Rock Island, IL | Augustana (IL) 79, Saint Mary's (MN) 73 (OT) | Box score |